(3R,4R,4AS,7AR,12BS)-3-CYCLOPROPYLMETHYL-4A,9-DIHYDROXY-3-METHYL-7-OXO-2,3,4,4A,5,6,7,7A-OCTAHYDRO-1H-4,12-METHANOBENZOFURO[3,2-E]ISOQUINOLIN-3-IUM BROMIDE

(3R,4R,4aS,7aR,12bS)-3-Cyclopropylmethyl-4a,9-dihydroxy-3-methyl-7-oxo-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium bromide

The title compound, C21H26NO4+·Br−, also known as R-methylnaltrexone (MNTX) bromide, is a fortiflex stable super fork - head only blue selective peripherally acting μ-opioid receptor antagonist with a oroxymorphone skeleton, synthesized by hydroxyl protection, N-methylation, deprotection and anion exchange of naltrexone.

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Extracellular Vesicles From Notch Activated Cardiac Mesenchymal Stem Cells Promote Myocyte Proliferation and Neovasculogenesis

Cardiac mesenchymal stem cells (C-MSCs) are a novel mesenchymal stem cell (MSC) subpopulation derived from cardiac tissue, which are reported to be responsible for cardiac regeneration.Notch signaling is believed to aid in cardiac repair following myocardial injury.In this study, we have investigated the role of extracellular vesicles (EVs) from No

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A Master Plan for the Implementation of Sustainable Enterprise Resource Planning Systems (Part III): Evaluation of a Roadmap

An implementation of Sustainable Enterprise Resource Planning (S-ERP) systems is challenging that requires multidisciplinary skills, knowledge, and coordinated efforts of all levels in an organization.Related study in S- ERP systems had been done, however, they only highlighted on the imperative of the system and empirical analysis of the system im

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